Isolated Perfusion Therapy for Advanced Cancers

Patients with cancer require effective treatment, including surgical resection, radiotherapy, and chemotherapy, but only a few options are available for the treatment of advanced cancer. Intensive drug exposure is fundamental to the eradication of cancers. However, adverse effects often prevent the administration of sufficient doses, resulting in poor antitumor responses [1]. Theoretically, isolated regional perfusion chemotherapy is an attractive option with which to achieve better tumor exposure to any given agent and to avoid systemic toxicity by decreasing the degree of systemic drug exposure [2].